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About Hepatitis B
Hepatitis B is a small, highly infectious, relatively resilient, double-shelled DNA virus that almost exclusively infects humans, and in some cases may even be capable of producing infection from environmental surfaces for more than 7 days at room temperature.1
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Certain populations are at risk for hepatitis B exposure4:
- Individuals exposed to blood containing hepatitis B surface antigen (HBsAg)
- Infants born to HBsAg-positive mothers
- Sex partners of HBsAg-positive persons
- Individuals exposed to HBsAg-positive persons within their household
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Postexposure Prophylaxis for Hepatitis B
HyperHEP B contains high titers of hepatitis B antibodies for postexposure prophylaxis (PEP), providing rapid immune protection with detectable levels of antibodies that persist for approximately 2 months or longer. When used in combination with hepatitis B vaccine, a hepatitis B immune globulin such as HyperHEP B offers maximum postexposure immune protection.4-6
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For individuals who have been exposed to hepatitis B, the Centers for Disease Control and Prevention (CDC) recommends PEP within approximately 24 hours.2,6 Learn more about the CDC recommendations.
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Prophylaxis Following Percutaneous or Permucosal Exposure4
Prophylaxis of Infants Born to HBsAg- and HBeAg-Positive Mothers4
Efficacy of prophylactic hepatitis B immune globulin (human) (HBIG) in infants at risk depends on administering HBIG on the day of birth. It is therefore vital that HBsAg-positive mothers be identified before delivery.
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Hepatitis B immune globulin (human) (0.5 mL) should be administered intramuscularly to the newborn infant after physiologic stabilization of the infant and preferably within 12 hours of birth. Hepatitis B immune globulin (human) efficacy decreases markedly if treatment is delayed beyond 48 hours.4
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Learn more about the Advisory Committee on Immunization Practices recommendations for infants born to HBV-infected mothers.
Prophylaxis for Sexual Exposure to Hepatitis B4
For more information about PEP in specific indications, please see the full Prescribing Information.
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- It is estimated that between 800,000 and 1.4 million people in the United States are currently infected with hepatitis B1,2
- If the mother is positive for both HBsAg and HBeAg, 70%–90% of infants will become infected in the absence of postexposure prophylaxis1
- An estimated 25,000 infants are born to HBsAg-positive mothers each year in the US3
- The hepatitis B virus is 50 to 100 times more infectious than HIV7
- The virus is transmitted through contact with the blood or other body fluids of an infected person, not through casual contact1